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Clin Perinatol. 2013 Sep;40(3):337-50. doi: 10.1016/j.clp.2013.05.015. Epub 2013 Jul 4.

Chronic opioid use during pregnancy: maternal and fetal implications.

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Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55902, USA.


Current trends in the United States suggest that chronic narcotic use has increased in reproductive aged women over the past 10 years. Regular exposure to such substances during pregnancy has maternal and fetal implications. Appropriate prenatal care is critical to optimizing outcomes. Management options for narcotic dependence should be patient-specific and may include discontinuation of narcotics with careful observation, limitation of prescription dispensing, or substitution therapy with methadone or buprenorphine. A multidisciplinary, collaborative approach is highly recommended. This review discusses usage of narcotic medications, associated maternal and fetal risks, and management strategies for the antepartum, intrapartum, and postpartum periods.


Buprenorphine; Methadone; Narcotic; Opioid; Pregnancy

[Indexed for MEDLINE]

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