A sweet solution, such as sucrose or glucose, can be used for analgesia for minor short term procedural pain, such as immunisation, in infants up to 12 months of age. The sweet solution is given orally and provides short term analgesia. It has National Health and Medical Research Council (NHMRC) Level I evidence of efficacy and no serious adverse effects have been reported. This article is part of a series on non drug treatments summarising indications, considerations, evidence and where clinicians and patients can get further information.