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Nat Rev Cancer. 2013 Sep;13(9):624-36. doi: 10.1038/nrc3589.

Zebrafish cancer: the state of the art and the path forward.

Author information

1
Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. whiter@mskcc.org

Abstract

The zebrafish is a recent addition to animal models of human cancer, and studies using this model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after mutagen exposure and through transgenesis. The tumours resemble human cancers at the histological, gene expression and genomic levels. The ability to carry out in vivo imaging, chemical and genetic screens, and high-throughput transgenesis offers a unique opportunity to functionally characterize the cancer genome. Moreover, increasingly sophisticated modelling of combinations of genetic and epigenetic alterations will allow the zebrafish to complement what can be achieved in other models, such as mouse and human cell culture systems.

PMID:
23969693
PMCID:
PMC6040891
DOI:
10.1038/nrc3589
[Indexed for MEDLINE]
Free PMC Article

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