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J Neuroimmunol. 2013 Oct 15;263(1-2):64-74. doi: 10.1016/j.jneuroim.2013.07.016. Epub 2013 Aug 6.

One calcitriol dose transiently increases Helios+ FoxP3+ T cells and ameliorates autoimmune demyelinating disease.

Author information

1
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, United States.

Abstract

Multiple sclerosis (MS) is an incurable inflammatory demyelinating disease. We investigated one calcitriol dose plus vitamin D3 (calcitriol/+D) as a demyelinating disease treatment in experimental autoimmune encephalomyelitis (EAE). Evidence that calcitriol-vitamin D receptor pathway deficits may promote MS, and data showing calcitriol enhancement of autoimmune T cell apoptosis provided the rationale. Whereas vitamin D3 alone was ineffective, calcitriol/+D transiently increased central nervous system (CNS) Helios(+)FoxP3(+) T cells and sustainably decreased CNS T cells, pathology, and neurological deficits in mice with EAE. Calcitriol/+D, which was more effective than methylprednisolone, has potential for reversing inflammatory demyelinating disease safely and cost-effectively.

KEYWORDS:

Autoimmunity; Encephalomyelitis; Methylprednisolone; Multiple sclerosis; Vitamin D

PMID:
23968560
DOI:
10.1016/j.jneuroim.2013.07.016
[Indexed for MEDLINE]

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