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Int J Gen Med. 2013 Aug 9;6:665-9. doi: 10.2147/IJGM.S47397. eCollection 2013.

Warfarin-induced calciphylaxis: a case report and review of literature.

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Staten Island University Hospital, Staten Island, NY, USA.


Calciphylaxis is a challenging complication of end-stage renal disease, with an unknown underlying mechanism. Several risk factors have been identified, such as hyperphosphatemia, hypercalcemia, hyperparathyroidism, low serum albumin levels, and history of warfarin therapy. This article presents a case of calciphylaxis provoked by reintroduction of warfarin therapy, introducing the possibility of direct induction.


ESRD; calciphylaxis; skin necrosis; warfarin

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