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Nutr Metab Insights. 2010 Jun 17;3:37-42. doi: 10.4137/NMI.S5044. eCollection 2010.

Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes After Zinc and Anti-oxidant Therapy.

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1
Research Director, Health Research Institute/Pfeiffer Treatment Center, 4575 Weaver Parkway, Warrenville, Illinois 60555.

Abstract

AIM:

To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression.

SUBJECTS AND METHODS:

Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs.

RESULTS:

Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls.

DISCUSSION:

These results suggest an association between Cu/Zn SOD serum levels and clinical depression.

KEYWORDS:

Cu/Zn SOD; depression; oxidative stress; super oxide dismutase

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