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Emerg Infect Dis. 2013;19(9):1521-4. doi: 10.3201/eid1909.130724.

R292K substitution and drug susceptibility of influenza A(H7N9) viruses.

Abstract

Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.

KEYWORDS:

H7N9; R292K; antimicrobial resistance; antiviral resistance; avian influenza; influenza; neuraminidase inhibitor; oseltamivir; recombinant neuraminidase; viruses; zanamivir

PMID:
23965618
PMCID:
PMC3810934
DOI:
10.3201/eid1909.130724
[Indexed for MEDLINE]
Free PMC Article

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