Synthesis and anti-histaminic activity of some novel pyrimidines

Sk A Rahaman; Y Rajendra Pasad; Phani Kumar; Bharath Kumar

doi:10.1016/j.jsps.2009.08.001

Synthesis and anti-histaminic activity of some novel pyrimidines

Saudi Pharm J. 2009 Jul;17(3):255-8. doi: 10.1016/j.jsps.2009.08.001.

Authors

Sk A Rahaman¹, Y Rajendra Pasad, Phani Kumar, Bharath Kumar

Affiliation

¹ Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada 520 010, AP, India.

Abstract

Novel pyrimidines were prepared by the condensation of chalcones of 4'-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1-5 were assigned on the basis of elemental analysis, IR, (1)H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine.

Keywords: Anti-histaminic activity; Chalcone; Pyrimidine.