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Adv Mater. 2013 Oct 25;25(40):5706-13. doi: 10.1002/adma.201302627. Epub 2013 Aug 20.

Enhanced efficacy of superparamagnetic iron oxide nanoparticles against antibiotic-resistant biofilms in the presence of metabolites.

Author information

1
Center for Biomedical Engineering, School of Engineering, Brown University, RI, USA, 02912.

Abstract

Antibiotic resistance and the lack of new antibacterial agents cause major challenges for the treatment of infections. Here, we describe a simple, broad-spectrum, and low-cost dual-sided approach which uses superparamagnetic iron oxide particles (SPION) in combination with fructose metabolites as an alternative to existing antibacterial strategies. This strategy offers further improved efficacy of SPION against persistent gram-positive and gram-negative bacteria infections by manipulating the biofilm metabolic microenvironment and outperforms vancomycin (the antibiotic of last resort), creating a new nanotechnology-driven approach.

KEYWORDS:

antibacterial; antibiotic resistance; biofilm; metabolic simulation; superparamagnetic iron oxide nanoparticles (SPION)

PMID:
23963848
DOI:
10.1002/adma.201302627
[Indexed for MEDLINE]

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