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Chem Commun (Camb). 2013 Oct 14;49(80):9134-6. doi: 10.1039/c3cc45360j. Epub 2013 Aug 21.

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1.

Author information

1
Department of Chemistry, The University of Hong Kong, Hong Kong, China. hsun@hku.hk.

Abstract

The N-terminus of hCTR1 was demonstrated to bind three Cu(+) ions tightly (log‚ÄČK = 14.92) and reversibly via its Met-rich motifs. Ag(+) binds to the protein with the same stoichiometry but much lower affinities than Cu(+). The protein also coordinates two Cu(2+) ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter.

PMID:
23962988
DOI:
10.1039/c3cc45360j
[Indexed for MEDLINE]

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