Format

Send to

Choose Destination
Curr Opin Microbiol. 2013 Dec;16(6):677-85. doi: 10.1016/j.mib.2013.07.019. Epub 2013 Aug 17.

Iron sparing and recycling in a compartmentalized cell.

Author information

1
University of California, Los Angeles, Box 951569, Los Angeles, CA 90095-1569, USA. Electronic address: cblaby@chem.ucla.edu.

Abstract

This review focuses on economizing, prioritizing and recycling iron in Chlamydomonas, a reference organism for discovering mechanisms of acclimation to poor iron nutrition in the plant lineage. The metabolic flexibility of Chlamydomonas offers a unique opportunity to distinguish the impact of iron nutrition on photosynthetic versus respiratory metabolism, and the contribution of subcellular compartments to iron storage and mobilization. Mechanisms of iron sparing include down regulation of protein abundance by transcript reduction or protein degradation. Two well-studied examples of hierarchical iron allocation are the maintenance of FeSOD in the plastid and heterotrophic metabolism in acetate-grown cells at the expense of photosynthetic metabolism. The latter implicates the existence of a pathway for inter-compartment iron recycling when access to iron becomes limiting.

PMID:
23962818
PMCID:
PMC3842415
DOI:
10.1016/j.mib.2013.07.019
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center