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ACS Nano. 2013 Sep 24;7(9):8089-97. doi: 10.1021/nn4033757. Epub 2013 Aug 20.

Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source.

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1
Koch Institute for Integrative Cancer Research, ¶Health Sciences and Technology, and #Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology , Cambridge, Massachusetts, United States.

Abstract

Plasmonic nanomaterials including gold nanorods are effective agents for inducing heating in tumors. Because near-infrared (NIR) light has traditionally been delivered using extracorporeal sources, most applications of plasmonic photothermal therapy have focused on isolated subcutaneous tumors. For more complex models of disease such as advanced ovarian cancer, one of the primary barriers to gold nanorod-based strategies is the adequate delivery of NIR light to tumors located at varying depths within the body. To address this limitation, a series of implanted NIR illumination sources are described for the specific heating of gold nanorod-containing tissues. Through computational modeling and ex vivo studies, a candidate device is identified and validated in a model of orthotopic ovarian cancer. As the therapeutic, imaging, and diagnostic applications of plasmonic nanomaterials progress, effective methods for NIR light delivery to challenging anatomical regions will complement ongoing efforts to advance plasmonic photothermal therapy toward clinical use.

PMID:
23961973
PMCID:
PMC3788585
DOI:
10.1021/nn4033757
[Indexed for MEDLINE]
Free PMC Article
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