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Allergy Asthma Clin Immunol. 2013 Aug 19;9(1):31. doi: 10.1186/1710-1492-9-31. eCollection 2013.

The effect of multiple allergen immunotherapy on exhaled nitric oxide in adults with allergic rhinitis.

Author information

  • 1Asthma, Allergy and Immunology Specialists, 875 County Line Road-Suite 107, Bryn Mawr, PA 19010, USA.
  • 2Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • 3Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Abstract

BACKGROUND:

There is a lack of objective measures of the clinical efficacy of allergen immunotherapy which relies on patients' perception about the effect of this treatment. We studied whether the fraction of exhaled nitric oxide is affected by multiple allergen immunotherapy in polysensitized adult subjects with allergic rhinitis. We also looked for associations between exhaled nitric oxide and subjects' demographics, symptom scores, and pulmonary function tests.

METHODS:

Twenty adult, polysensitized subjects with seasonal and perennial allergic rhinitis who chose to undergo allergen immunotherapy were enrolled. They were evaluated at baseline, and 4, 8, 12, 24, and 52 weeks later. Exhaled nitric oxide was reported as the mean of triplicate determinations.

FINDINGS:

Our results indicate that multiple allergen immunotherapy did not affect exhaled nitric oxide levels and such levels did not correlate with subjects' demographics and pulmonary function tests. However, exhaled nitric oxide was associated with rhinoconjuctivitis and asthma symptom scores at the end of the study.

CONCLUSIONS:

In polysensitized adult subjects with allergic rhinitis, exhaled nitric oxide levels are unaffected by multiple allergen immunotherapy.

KEYWORDS:

Allergen immunotherapy; Allergic rhinitis; Nitric oxide

PMID:
23958488
PMCID:
PMC3751795
DOI:
10.1186/1710-1492-9-31
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