Format

Send to

Choose Destination
Exp Cell Res. 2013 Dec 10;319(20):3059-64. doi: 10.1016/j.yexcr.2013.07.031. Epub 2013 Aug 16.

miR-128 and its target genes in tumorigenesis and metastasis.

Author information

1
Dalian Medical University, Dalian 116044, China. Electronic address: molin_li@hotmail.com.

Abstract

MicroRNAs (miRNAs) are a class of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis.

KEYWORDS:

Metastasis; MicroRNA-128 (miR-128); Target genes; Tumorigenesis

PMID:
23958464
DOI:
10.1016/j.yexcr.2013.07.031
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center