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Exp Cell Res. 2013 Dec 10;319(20):3059-64. doi: 10.1016/j.yexcr.2013.07.031. Epub 2013 Aug 16.

miR-128 and its target genes in tumorigenesis and metastasis.

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Dalian Medical University, Dalian 116044, China. Electronic address:


MicroRNAs (miRNAs) are a class of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis.


Metastasis; MicroRNA-128 (miR-128); Target genes; Tumorigenesis

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