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Mutat Res. 2013 Oct;750(1-2):56-66. doi: 10.1016/j.mrfmmm.2013.08.001. Epub 2013 Aug 16.

Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin.

Author information

1
University of Southern California, 1050 Childs Way, Los Angeles, CA, United States. Electronic address: chiolo@usc.edu.

Abstract

Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity. While much is known about the molecular mechanisms involved in DSB repair and checkpoint activation, the roles of nuclear dynamics of radiation-induced foci (RIF) in DNA repair are just beginning to emerge. Here, we summarize results from recent studies that point to distinct features of these dynamics in two different chromatin environments: heterochromatin and euchromatin. We also discuss how nuclear architecture and chromatin components might control these dynamics, and the need of novel quantification methods for a better description and interpretation of these phenomena. These studies are expected to provide new biomarkers for radiation risk and new strategies for cancer detection and treatment.

KEYWORDS:

Biomarker; Cancer risk; Chromatin dynamics; DSB response; Ionizing radiation; Modeling

PMID:
23958412
PMCID:
PMC3838906
DOI:
10.1016/j.mrfmmm.2013.08.001
[Indexed for MEDLINE]
Free PMC Article
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