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Trends Cell Biol. 2013 Dec;23(12):620-33. doi: 10.1016/j.tcb.2013.07.006. Epub 2013 Aug 16.

Evading apoptosis in cancer.

Author information

1
Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

Abstract

Carcinogenesis is a mechanistically complex and variable process with a plethora of underlying genetic causes. Cancer development comprises a multitude of steps that occur progressively starting with initial driver mutations leading to tumorigenesis and, ultimately, metastasis. During these transitions, cancer cells accumulate a series of genetic alterations that confer on the cells an unwarranted survival and proliferative advantage. During the course of development, however, cancer cells also encounter a physiologically ubiquitous cellular program that aims to eliminate damaged or abnormal cells: apoptosis. Thus, it is essential that cancer cells acquire instruments to circumvent programmed cell death. Here we discuss emerging evidence indicating how cancer cells adopt various strategies to override apoptosis, including amplifying the antiapoptotic machinery, downregulating the proapoptotic program, or both.

KEYWORDS:

BH3; MOMP; caspase; phosphorylation; ubiquitination

PMID:
23958396
PMCID:
PMC4091735
DOI:
10.1016/j.tcb.2013.07.006
[Indexed for MEDLINE]
Free PMC Article
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