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Trends Immunol. 2013 Sep;34(9):423-30. doi: 10.1016/j.it.2013.07.001. Epub 2013 Aug 16.

Impact of the gut microbiome on mucosal inflammation.

Author information

1
National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA. Electronic address: Wstrober@niaid.nih.gov.

Abstract

In the past 10 years it has become increasingly apparent that the gut microbiome has profound effects on the immune system to which it is juxtaposed, the mucosal immune system. Here, I explore recent studies in which the effects of the microbiota expand or facilitate anti-inflammatory or regulatory immunological machinery or which favor development of proinflammatory immunological machinery in this system. I then focus on how these opposing processes play out in inflammatory bowel disease (IBD); a disease in which normal immune homeostasis is disturbed and inflammation takes hold.

KEYWORDS:

Anti-inflammatory organisms; Gut microbiome; Inflammatory Bowel Disease; Mucosal regulatory T cells; Proinflammatory (colitogenic organisms)

PMID:
23957963
PMCID:
PMC3773492
DOI:
10.1016/j.it.2013.07.001
[Indexed for MEDLINE]
Free PMC Article

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