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Annu Rev Physiol. 2014;76:1-20. doi: 10.1146/annurev-physiol-021113-170355. Epub 2013 Aug 19.

A conversation with Leonard and Leonore Herzenberg.

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1
Department of Genetics, Stanford University, Stanford, California 94305.

Abstract

Leonard and Leonore Herzenberg have left an indelible mark on the fields of immunology and cell biology, both in research and clinical aspects. They are perhaps best known for developing the technologies of fluorescence flow cytometry and hybridomas. Over six decades, they made a number of important and fundamental discoveries in lymphocyte biology by applying these technologies. During this era, they immersed themselves in the sociopolitical environment, interjecting scientific rationale into public discourse about McCarthyism, nuclear fallout, war, genetics, and other politically charged topics. Their unique philosophy has shaped their lives, their science, and ultimately the scientific community. In this Conversation, we explore some of these driving forces and the impact on the laboratory.

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