Format

Send to

Choose Destination
See comment in PubMed Commons below
Rheumatology (Oxford). 2014 Feb;53(2):223-32. doi: 10.1093/rheumatology/ket277. Epub 2013 Aug 16.

Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins?

Author information

1
Department of Rheumatology, Ghent University, De Pintelaan 185, 9000 Gent, Belgium. stijn.lambrecht@ugent.be.

Abstract

Heat-shock proteins (HSPs) are molecular chaperones that are highly conserved between species. In recent decades it has become clear that these proteins play an important role in the pathogenesis of inflammatory and degenerative joint diseases by (dys)regulating the immune system and by direct effects on the stromal tissues of the joint. In this review we discuss current insights into the expression pattern of HSPs in connective tissues, the direct biological role of HSPs in stromal tissues and the potential clinical applications.

KEYWORDS:

arthritis; connective; osteoarthritis; stress response; tissue inflammation

PMID:
23955645
DOI:
10.1093/rheumatology/ket277
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center