Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Genet. 2013 Oct;45(10):1221-1225. doi: 10.1038/ng.2733. Epub 2013 Aug 18.

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

Author information

1
Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
2
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
3
German Cancer Research Center, Heidelberg, Germany.
4
Haemato-Oncology, Division of Pathology, Institute of Cancer Research, Surrey, UK.
5
Center for Primary Health Care Research, Lund University, Malmo, Sweden.
6
National Centre of Tumour Diseases, Heidelberg, Germany.
7
University of Leeds, Leeds, UK.
8
Royal Victoria Infirmary, Newcastle upon Tyne, UK.
9
Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle-upon-Tyne, UK.
10
Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK.
11
Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK.
12
Leeds Teaching Hospitals NHS Trust, Leeds, UK.
13
Institute of Human Genetics, University of Bonn, Germany.
14
Department of Genomics, University of Bonn, Germany.
15
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
16
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Germany.
17
Cytogenetics Group, Wessex Regional Cytogenetic Laboratory, Salisbury, UK.
18
Schön Klinik Starnberger See, Berg, Germany.
19
University Clinic of Würzburg, Würzburg, Germany.
20
Department of Internal Medicine III, University of Ulm, Ulm, Germany.
21
Institute of Human Genetics, University of Heidelberg, Germany.
#
Contributed equally

Abstract

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

PMID:
23955597
PMCID:
PMC5053356
DOI:
10.1038/ng.2733
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center