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Chemistry. 2013 Sep 9;19(37):12249-53. doi: 10.1002/chem.201300961. Epub 2013 Aug 16.

Efficient metal-free synthesis of various pyrido[2',1':2,3]imidazo- [4,5-b]quinolines.

Author information

1
Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067 Orléans cedex 2 (France), Fax: (+33) 2-38-41-72-81.

Abstract

Dancing with diversity: The synthesis of diverse pyrido[2',1':2,3]imidazo[4,5-b]quinolines bearing several substitution patterns was developed based on combining a multicomponent reaction (Groebke-Blackburn-Bienaymé reaction) with an original cyclization as a secondary transformation (see scheme; DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).

KEYWORDS:

Groebke-Blackburn-Bienaymé reaction; aromatic cyclization; cyclization; diversity-oriented synthesis; multicomponent reactions

PMID:
23955568
DOI:
10.1002/chem.201300961
[Indexed for MEDLINE]
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