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Am J Ind Med. 2014 Mar;57(3):303-11. doi: 10.1002/ajim.22244. Epub 2013 Aug 19.

Cleaning and asthma characteristics in women.

Author information

1
Inserm, Center for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, F-94807, Villejuif, France; Univ Paris-Sud, UMRS 1018, F-94807, Villejuif, France.

Abstract

BACKGROUND:

We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, immunological and inflammatory aspects.

METHODS:

Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed).

RESULTS:

Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2-6.4)) and severe asthma (5.1(1.7-15.3)). An association was suggested for poorly controlled asthma (2.2(0.9-5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1-8.3)), with a low IgE level (2.8(1.2-6.2)), and with a low eosinophil count (3.2(1.5-7.1)).

CONCLUSIONS:

Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures.

KEYWORDS:

asthma characteristics; cleaning product; occupational asthma; occupational exposure; work-related asthma

PMID:
23955502
DOI:
10.1002/ajim.22244
[Indexed for MEDLINE]
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