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Curr Neurol Neurosci Rep. 2013 Oct;13(10):381. doi: 10.1007/s11910-013-0381-0.

Genome-wide association studies in Alzheimer's disease: a review.

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1
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Abstract

Over the past decade, research aiming to disentangle the genetic underpinnings of late-onset Alzheimer's disease has mostly focused on the identification of common variants through genome-wide association studies. The identification of several new susceptibility genes through these efforts has reinforced the importance of amyloid precursor protein and tau metabolism in the cause of the disease and has implicated immune response, inflammation, lipid metabolism, endocytosis/intracellular trafficking, and cell migration in the cause of the disease. Ongoing and future large-scale genome-wide association studies, translational studies, and next-generation whole genome or whole exome sequencing efforts, hold the promise to map the specific causative variants in these genes, to identify several additional risk variants, including rare and structural variants, and to identify novel targets for genetic testing, prevention, and treatment.

PMID:
23954969
PMCID:
PMC3809844
DOI:
10.1007/s11910-013-0381-0
[Indexed for MEDLINE]
Free PMC Article
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