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Pediatr Nephrol. 2014 Apr;29(4):531-6. doi: 10.1007/s00467-013-2589-2. Epub 2013 Aug 20.

Bone morphogenetic protein signaling in nephron progenitor cells.

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1
Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04106, USA, oxburl@mmc.org.

Abstract

Bone morphogenetic protein (BMP) signaling plays an essential role in many aspects of kidney development, and is a major determinant of outcome in kidney injury. BMP treatment is also an essential component of protocols for differentiation of nephron progenitors from pluripotent stem cells. This review discusses the role of BMP signaling to nephron progenitor cells in each of these contexts.

PMID:
23954916
PMCID:
PMC3944211
DOI:
10.1007/s00467-013-2589-2
[Indexed for MEDLINE]
Free PMC Article
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