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Exp Cell Res. 2013 Nov 1;319(18):2759-69. doi: 10.1016/j.yexcr.2013.08.008. Epub 2013 Aug 13.

Clathrin-independent endocytosis: a cargo-centric view.

Author information

1
Cell Biology & Physiology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.

Abstract

Clathrin-independent endocytosis occurs in all cells and interest in this mode of cellular entry has grown. Although this form of endocytosis was first described for entry of bacterial toxins, here we focus our attention on the endogenous cell surface "cargo" proteins that enter cells by this mechanism. The cargo proteins entering by this mechanism are varied and include nutrient transporters, ion channels, cell adhesion molecules and proteins associated with the immune system. Despite the apparent lack of selection at the cell surface, we provide some examples of specific sorting of these cargo proteins after entry, leading to distinct itineraries and cellular fates.

KEYWORDS:

Cell adhesion molecules; Clathrin-independent endocytosis; Endocytosis; Ion channels; Nutrient transporters; Plasma membrane protein; Protein sorting

PMID:
23954817
PMCID:
PMC4157725
DOI:
10.1016/j.yexcr.2013.08.008
[Indexed for MEDLINE]
Free PMC Article

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