Format

Send to

Choose Destination
J Hepatol. 2013 Dec;59(6):1177-83. doi: 10.1016/j.jhep.2013.08.002. Epub 2013 Aug 13.

Targeted vaccination programme successful in reducing acute hepatitis B in men having sex with men in Amsterdam, the Netherlands.

Author information

1
Public Health Service Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands. Electronic address: gvrijckevorsel@ggd.amsterdam.nl.

Abstract

BACKGROUND & AIMS:

In the Netherlands, transmission of hepatitis B virus occurs mainly within behavioural high-risk groups, such as in men who have sex with men. Therefore, a vaccination programme has targeted these high-risk groups. This study evaluates the impact of the vaccination programme targeting Amsterdam's large population of men who have sex with men from 1998 through 2011.

METHODS:

We used Amsterdam data from the national database of the vaccination programme for high-risk groups (January 1, 1998 to December 31, 2011). Programme and vaccination coverage were estimated with population statistics. Incidence of acute hepatitis B was analyzed with notification data from the Amsterdam Public Health Service (1992-2011). Mathematical modelling accounting for vaccination data and trends in sexual risk behaviour was used to explore the impact of the programme.

RESULTS:

At the end of 2011, programme coverage was estimated at 41% and vaccination coverage from 30% to 38%. Most participants (67%) were recruited from the outpatient department for sexually transmitted infections and outreach locations such as saunas and gay bars. Incidence of acute hepatitis B dropped sharply after 2005. The mathematical model in which those who engage most in high-risk sex are vaccinated, best explained the decline in incidence.

CONCLUSIONS:

Transmission of hepatitis B virus among Amsterdam's men who have sex with men has decreased, despite ongoing high-risk sexual behaviour. Vaccination programmes targeting men who have sex with men do not require full coverage; they may be effective when those who engage most in high-risk sex are reached.

KEYWORDS:

95% CI; 95% confidence interval; APC; HBV; HbsAg; Hepatitis B; IQR; MSM; Men who have sex with men; PHS; Prevention; Public Health Service; RR; Risk group; STI-OPD; UAI; Vaccination programme; age-period-cohort; anti-HBc; antibodies against hepatitis B core antigen; hepatitis B surface antigen; hepatitis B virus; incidence rate ratios; interquartile range; men who have sex with men; outpatient department for sexually transmitted infections; unprotected anal intercourse

PMID:
23954670
DOI:
10.1016/j.jhep.2013.08.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center