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Virus Res. 2013 Dec 5;178(1):15-20. doi: 10.1016/j.virusres.2013.07.017. Epub 2013 Aug 13.

Transmission of influenza A/H5N1 viruses in mammals.

Author information

1
Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan.

Abstract

Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness.

KEYWORDS:

Airborne transmission; Avian H5N1 influenza A virus; Mammalian model

PMID:
23954580
PMCID:
PMC3838911
DOI:
10.1016/j.virusres.2013.07.017
[Indexed for MEDLINE]
Free PMC Article

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