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Methods. 2014 Mar 1;66(1):22-33. doi: 10.1016/j.ymeth.2013.08.005. Epub 2013 Aug 15.

Cow's milk allergy: from allergens to new forms of diagnosis, therapy and prevention.

Author information

1
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Austria. Electronic address: heidrun.hochwallner@meduniwien.ac.at.
2
Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Austria.
3
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Austria.

Abstract

The first adverse reactions to cow's milk were already described 2,000 years ago. However, it was only 50 years ago that several groups started with the analysis of cow's milk allergens. Meanwhile the spectrum of allergy eliciting proteins within cow's milk is identified and several cow's milk allergens have been characterized regarding their biochemical properties, fold and IgE binding epitopes. The diagnosis of cow's milk allergy is diverse ranging from fast and cheap in vitro assays to elaborate in vivo assays. Considerable effort was spent to improve the diagnosis from an extract-based into a component resolved concept. There is still no suitable therapy available against cow's milk allergy except avoidance. Therefore research needs to focus on the development of suitable and safe immunotherapies that do not elicit severe side effect.

KEYWORDS:

Diagnosis; Microarray; Milk allergy; Recombinant allergens; Therapy

PMID:
23954566
PMCID:
PMC3969108
DOI:
10.1016/j.ymeth.2013.08.005
[Indexed for MEDLINE]
Free PMC Article

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