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Trends Cardiovasc Med. 2014 Jan;24(1):7-13. doi: 10.1016/j.tcm.2013.05.003. Epub 2013 Aug 15.

Modeling myocardial growth and hypertrophy in engineered heart muscle.

Author information

1
Institute of Pharmacology, Heart Research Center Göttingen, University Medical Center Göttingen, Georg-August-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner site Göttingen, Göttingen, Germany.
2
Institute of Pharmacology, Heart Research Center Göttingen, University Medical Center Göttingen, Georg-August-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner site Göttingen, Göttingen, Germany. Electronic address: w.zimmermann@med.uni-goettingen.de.

Abstract

The introduction of biomimetic culture paradigms has advanced myocardial tissue engineering fundamentally, enabling today the provision of engineered rodent and human heart muscle with features characteristically found in postnatal myocardium. This is in marked contrasts to "flat" cardiomyocyte cultures with their typically low degree of organotypic maturation. Here, we discuss the collagen hydrogel-based engineered heart muscle (EHM) technology and provide background information on its use in simulations of myocardial growth and disease.

PMID:
23953977
DOI:
10.1016/j.tcm.2013.05.003
[Indexed for MEDLINE]

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