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Semin Nephrol. 2013 May;33(3):248-56. doi: 10.1016/j.semnephrol.2013.04.005.

Gut sensing of potassium intake and its role in potassium homeostasis.

Author information

1
Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA 90089-9142, USA. youn@usc.edu

Abstract

Extracellular K(+) homeostasis has been explained by feedback mechanisms in which changes in extracellular K(+) concentration drive renal K(+) excretion directly or indirectly via stimulating aldosterone secretion. However, this cannot explain meal-induced kaliuresis, which often occurs without increases in plasma K(+) or aldosterone concentrations. Recent studies have produced evidence supporting a feedforward control in which gut sensing of dietary K(+) increases renal K(+) excretion (and extrarenal K(+) uptake) independent of plasma K(+) concentrations, namely, a gut factor. This review focuses on these new findings and discusses the role of gut factor in acute and chronic regulation of extracellular K(+) as well as in the beneficial effects of high K(+) intake on the cardiovascular system.

KEYWORDS:

Potassium excretion; feedback control; feedforward control; potassium adaptation; potassium balance

PMID:
23953802
PMCID:
PMC3748407
DOI:
10.1016/j.semnephrol.2013.04.005
[Indexed for MEDLINE]
Free PMC Article

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