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Cell. 2013 Aug 15;154(4):718-20. doi: 10.1016/j.cell.2013.07.041.

A cluster to remember.

Author information

1
Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Based on a massive transcription factor location analysis within a single cell type, in this issue Yan et al. find that the great majority of occupancies occur within dense clusters of up to 100 factors that almost invariably contain cohesins. Retention of cohesins at cluster sites during mitosis raises the possibility that they contribute to transcriptional memory during the cell cycle.

PMID:
23953105
PMCID:
PMC3878159
DOI:
10.1016/j.cell.2013.07.041
[Indexed for MEDLINE]
Free PMC Article

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