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Semin Ophthalmol. 2015 Jan;30(1):6-10. doi: 10.3109/08820538.2013.807852. Epub 2013 Aug 16.

The effect of intravitreal anti-VEGF on the pigment epithelial detachment in eyes with the exudative type of age-related macular degeneration.

Author information

1
University of Crete Medical School, Department of Ophthalmology , Heraklion , Greece.

Abstract

PURPOSE:

To evaluate the effect of anti-VEGF treatment on pigment epithelial detachment (PED) secondary to the exudative type of age-related macular degeneration (AMD).

METHODS:

Retrospective analysis of 30 eyes (28 patients) with exudative AMD accompanied by PED (receiving anti-VEGF injections). Alterations of the PED morphology were qualitatively assessed with optical coherence tomography (OCT). Changes in best-corrected visual acuity (BCVA) and number of injections were compared to 30 control eyes (30 patients) exhibiting exudative AMD without PED.

RESULTS:

Mean follow-up was 19.8 months. Changes of the extent of PED were as follows: unchanged: 11 eyes (36.7%); reduced: 12 (40%); significantly reduced: 7 (23.3%). Mean paired difference in BCVA was -0.08 logMAR (pā€‰=ā€‰0.46) and in the number of injections was 2.1 injections (pā€‰=ā€‰0.04).

CONCLUSIONS:

A substantial number of the studied patients showed reduction of the extent of the PED after anti-VEGF treatment. The PED group required a higher number of injections.

KEYWORDS:

Choroidal neovascularization; VEGF; optical coherence tomography; ranibizumab

PMID:
23952911
DOI:
10.3109/08820538.2013.807852
[Indexed for MEDLINE]

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