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Lik Sprava. 2013 Jan-Feb;(1):30-41.

[About etiology and pathogenesis of atherosclerosis].

[Article in Russian]


On the ground own researches and researches of other authors etiology and pathogenesis of atherosclerosis are proved and refuted existing concept about leading role of disturbance of lipid exchange and atherogenicity of lipoproteins of low and very low density. Established basic etiological factors of damage intima of artery and reason of penetration of lipoproteins in intima after her damage. Is determined that development and progression of atherosclerosis do not depend also from quantitative content of lipoproteins of low density in blood and from normalization of them under influence of drugs. According to our researches atherosclerosis is the polyetiological chronic disease basis of pathogeny which is infringement of blood supply (chronic microcirculatory insufficiency) in arterial wall causing damage of it, and in first place, damage of intima with her most vulnerable microcirculation; inflammation intima hence influence of endogenous and exogenous factors; destruction of antiaggregatic and fibrinolytic properties of intima in places of her damage; formation atherosclerotic plaque with level-by-level imposing of lipoproteins in result of cyclic process of restoration or balance between coagulation and anticoagulation of blood systems.

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