Format

Send to

Choose Destination
Cancer Epidemiol Biomarkers Prev. 2013 Oct;22(10):1853-61. doi: 10.1158/1055-9965.EPI-13-0560. Epub 2013 Aug 15.

Reproductive factors, heterogeneity, and breast tumor subtypes in women of mexican descent.

Author information

1
Authors' Affiliations: Moores Cancer Center; Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California; Arizona Cancer Center, University of Arizona, Tucson; Department of Surgery, Maricopa Medical Center, Phoenix, Arizona; Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine; University of Texas M.D. Anderson Cancer Center, Houston, Texas; Universidad of Guadalajara, Guadalajara; Instituto Tecnológico de Sonora, Ciudad Obregón; and Universidad of Sonora, Hermosillo, Mexico.

Abstract

BACKGROUND:

Published data support the presence of etiologic heterogeneity by breast tumor subtype, but few studies have assessed this in Hispanic populations.

METHODS:

We assessed tumor subtype prevalence and associations between reproductive factors and tumor subtypes in 1,041 women of Mexican descent enrolled in a case-only, binational breast cancer study. Multinomial logistic regression comparing HER2(+) tumors and triple-negative breast cancer (TNBC) to luminal A tumors was conducted.

RESULTS:

Compared with women with luminal A tumors, those with a later age at first pregnancy were less likely to have TNBC [OR, 0.61; 95% confidence interval (CI), 0.39-0.95], whereas those with three or more full-term pregnancies were more likely to have TNBC (OR, 1.68; 95% CI, 1.10-2.55). A lower odds of TNBC was shown for longer menstruation duration, whether before first pregnancy (OR, 0.78; 95% CI, 0.65-0.93 per 10 years) or menopause (OR, 0.79; 95% CI, 0.69-0.91 per 10 years). Patients who reported breastfeeding for more than 12 months were over twice as likely to have TNBC than luminal A tumors (OR, 2.14; 95% CI, 1.24-3.68). Associations comparing HER2(+) with luminal A tumors were weak or nonexistent except for the interval between last full-term pregnancy and breast cancer diagnosis.

CONCLUSIONS:

Findings show etiologic heterogeneity by tumor subtype in a population of Hispanic women with unique reproductive profiles.

IMPACT:

Identification of etiologically distinct breast tumor subtypes can further improve our understanding of the disease and help provide personalized prevention and treatment regimens.

PMID:
23950213
PMCID:
PMC3799795
DOI:
10.1158/1055-9965.EPI-13-0560
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center