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J Invest Dermatol. 2013 Sep;133(9):2130-3. doi: 10.1038/jid.2013.261.

Nuclear topology, epigenetics, and keratinocyte differentiation.

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1
National Cheng Kung University School of Medicine, Tainan, Taiwan. z10110045@email.ncku.edu.tw

Abstract

Recent progress in epigenetics reveals dynamic chromatin interactions in the nucleus during development, regeneration, reprogramming, and in disease. Higher-order chromatin organization is manifested as changes in the topological distribution of eu-/heterochromatin and in nuclear morphology. We are now able to gain new knowledge about these changes at the genomic level.

PMID:
23949766
DOI:
10.1038/jid.2013.261
[Indexed for MEDLINE]
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