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Toxins (Basel). 2013 Aug 14;5(8):1402-21. doi: 10.3390/toxins5081402.

Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma.

Author information

1
Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.

Abstract

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

PMID:
23949004
PMCID:
PMC3760043
DOI:
10.3390/toxins5081402
[Indexed for MEDLINE]
Free PMC Article

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