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Cancer Cell. 2013 Aug 12;24(2):143-4. doi: 10.1016/j.ccr.2013.07.016.

The origins of tumor-promoting inflammation.

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1
HHMI and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 0651, USA.

Abstract

Inflammation is increasingly recognized as an essential component of tumor development, but the origin of tumor-associated inflammation remains largely unknown. In this issue of Cancer Cell, Pribluda and colleagues find that chronic stress initiates senescence-inflammatory response, which can promote tumorigenesis in the absence of exogenous inflammatory triggers.

PMID:
23948294
PMCID:
PMC3786430
DOI:
10.1016/j.ccr.2013.07.016
[Indexed for MEDLINE]
Free PMC Article
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