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Obes Rev. 2013 Dec;14(12):950-9. doi: 10.1111/obr.12068. Epub 2013 Aug 16.

Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?

Author information

1
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.

Abstract

It is increasingly recognized that there is a connection between diet, intestinal microbiota, intestinal barrier function and the low-grade inflammation that characterizes the progression from obesity to metabolic disturbances, making dietary strategies to modulate the intestinal environment relevant. In this context, the ability of some Gram-positive anaerobic bacteria to produce the short-chain fatty acid butyrate is interesting. A lower abundance of butyrate-producing bacteria has been associated with metabolic risk in humans, and recent studies suggest that butyrate might have an anti-inflammatory potential that can alleviate obesity-related metabolic complications, possibly due to its ability to enhance the intestinal barrier function. Here, we review and discuss the potential of butyrate as an anti-inflammatory mediator in metabolic diseases, and the potential for dietary interventions increasing the intestinal availability of butyrate.

KEYWORDS:

Butyrate; butyrate-producing bacteria; intestinal microbiota; obesity-related diseases

PMID:
23947604
DOI:
10.1111/obr.12068
[Indexed for MEDLINE]

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