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Korean J Physiol Pharmacol. 2013 Aug;17(4):359-65. doi: 10.4196/kjpp.2013.17.4.359. Epub 2013 Jul 30.

Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse.

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  • 1Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine, Cheongju 361-763, Korea.

Abstract

Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K(+) channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K(+) conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular muscle of mouse. Furthermore, contractility was significantly increased in pregnant uterine circular muscle than that of non-pregnant muscle. These patterns were not changed even in the presence of tetraetylammonium (TEA) and 4-aminopyridine (4-AP). Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretchactivated channels in myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed increased immunohistochemical expression of TASK-2. Therefore, TASK-2, seems to play a key role during regulation of myometrial contractility in the pregnancy and provides new insight into preventing preterm delivery.

KEYWORDS:

Relaxation; TASK-2; Uterus

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