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Neurology. 2013 Oct 1;81(14):1222-5. doi: 10.1212/WNL.0b013e3182a6cc13. Epub 2013 Aug 14.

Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study.

Author information

1
From the Oxford University Nuffield Department of Clinical Neurosciences (M.R.T., K.T.), John Radcliffe Hospital; Oxford University Unit of Health-Care Epidemiology (R.G., M.J.G.), Department of Public Health; and Oxford University Department of Physiology, Anatomy and Genetics (S.R.), Oxford, UK.

Abstract

OBJECTIVE:

To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease.

METHODS:

An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease.

RESULTS:

There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis.

CONCLUSIONS:

Autoimmune disease associations with ALS raise the possibility of shared genetic or environmental risk factors.

PMID:
23946298
PMCID:
PMC3795611
DOI:
10.1212/WNL.0b013e3182a6cc13
[Indexed for MEDLINE]
Free PMC Article

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