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Org Lett. 2013 Sep 6;15(17):4446-9. doi: 10.1021/ol401991u. Epub 2013 Aug 14.

Scopariusic acid, a new meroditerpenoid with a unique cyclobutane ring isolated from Isodon scoparius.

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1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.

Abstract

Scopariusic acid (1), a new ent-clerodane-based meroditerpenoid with a unique cyclobutane ring and an unusual 1-octen-3-ol substituent, together with its biosynthetic related compound 2, were isolated from the aerial parts of Isodon scoparius. The structures of 1 and 2, including their absolute configurations, were determined by spectroscopic methods, single-crystal X-ray diffraction analysis, and chemical methods. Compound 1 showed weak cytotoxicity and moderate immunosuppressive activity.

PMID:
23944990
DOI:
10.1021/ol401991u
[Indexed for MEDLINE]
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