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Zhongguo Zhong Yao Za Zhi. 2013 May;38(9):1360-5.

[Evaluation of balanced release of complex components of Chuanping sustained tablets based on fingerprint].

[Article in Chinese]

Author information

1
Research Institute of Traditional Chinese Medicine Development, Guangdong Pharmnacological University, Guangzhou, China.

Abstract

To combine fingerprint and drug release rate in vitro, in order to study in vitro release of complex components of Chuanping sustained tablets, compound traditional Chinese medicine preparation. A qualitative determination of the characteristic peaks of the compound preparations were conducted by the fingerprint. The results of the dissolution rate determination under different release conditions showed that the release of three index components (methamphetamine, pseudoephedrine and scopolamine) of Chuanping sustained tablets was less affected by gastrointestinal factors, with similarity factors being more than 80 with unknown component release curves of three major characteristic peaks in the fingerprint. The qualitative determination proved that multiple components of the compound traditional Chinese medicine preparation was dissolved in vitro at similar rates, realizing the balanced release of complex components of the compound traditional Chinese medicine preparation. This study layed a theoretical and experimental basis for quality evaluation for the compound traditional Chinese medicine preparation.

PMID:
23944069
[Indexed for MEDLINE]

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