Abstract
The amphiphilic block copolymer, composed of hydrophilic dextran sulfate as the targeting ligand and hydrophobic polycaprolactone as the hydrophobic segment, was prepared via click chemistry to develop self-assembled nanoparticles for targeting rheumatoid arthritis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arthritis, Rheumatoid / drug therapy*
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Click Chemistry
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Dextran Sulfate / chemistry*
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Drug Carriers / chemistry*
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Hydrophobic and Hydrophilic Interactions
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Mice
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Molecular Targeted Therapy*
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Nanoparticles / chemistry*
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Polyesters / chemistry
Substances
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Drug Carriers
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Polyesters
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polycaprolactone
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Dextran Sulfate