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Nat Rev Mol Cell Biol. 2013 Sep;14(9):581-91. doi: 10.1038/nrm3639. Epub 2013 Aug 14.

Mechanisms and mechanics of cell competition in epithelia.

Author information

1
Medical Research Council (MRC) National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. jvincen@nimr.mrc.ac.uk

Abstract

When fast-growing cells are confronted with slow-growing cells in a mosaic tissue, the slow-growing cells are often progressively eliminated by apoptosis through a process known as cell competition. The underlying signalling pathways remain unknown, but recent findings have shown that cell crowding within an epithelium leads to the eviction of cells from the epithelial sheet. This suggests that mechanical forces could contribute to cell elimination during cell competition.

PMID:
23942450
DOI:
10.1038/nrm3639
[Indexed for MEDLINE]

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