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Cancer Lett. 2014 Apr 10;345(2):174-81. doi: 10.1016/j.canlet.2013.07.030. Epub 2013 Aug 11.

Virus induced inflammation and cancer development.

Author information

1
Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, Australia.
2
Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, Australia; Centre for Infectious Diseases and Microbiology, Marie Bashir Institute for Infectious Diseases and Biosecurity University of Sydney at Westmead Hospital, Sydney, Australia. Electronic address: mark.douglas@sydney.edu.au.

Abstract

Chronic inflammation as a result of viral infection significantly increases the likelihood of cancer development. A handful of diverse viruses have confirmed roles in cancer development and progression, but the list of suspected oncogenic viruses is continually growing. Viruses induce cancer directly and indirectly, by activating inflammatory signalling pathways and cytokines, stimulating growth of infected cells and inhibiting apoptosis. Although oncogenic viruses induce inflammation by various mechanisms, it is generally mediated by the MAPK, NFκB and STAT3 signalling pathways. This review will explore the unique mechanisms by which different oncogenic viruses induce inflammation to promote cancer initiation and progression.

KEYWORDS:

Cancer; Inflammation; Review; Viruses

PMID:
23941825
DOI:
10.1016/j.canlet.2013.07.030
[Indexed for MEDLINE]
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