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Dement Geriatr Cogn Disord. 2013;36(3-4):211-28. doi: 10.1159/000353892. Epub 2013 Aug 12.

Pharmacological treatment of dementia: a scoping review of systematic reviews.

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1
Section of Geriatrics, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Abstract

BACKGROUND:

Until now, multiple reviews on the pharmacological treatment of dementia have been published.

METHODS:

We performed a scoping review to summarize research findings and to identify gaps in the existing literature. We searched the literature and assessed the risk of bias of the included reviews. A team of clinical experts assessed the fields in which more research is necessary. Fifty-five reviews with a low risk of bias were included, most of them concerning the treatment of cognitive decline (n = 16) and behavioral symptoms (n = 10) in Alzheimer's disease (AD). For cognitive impairment, cholinesterase inhibitors (n = 13) and memantine (n = 7) were described most frequently. Little information was found about the treatment of depression in dementia.

CONCLUSIONS:

For many current treatments, there is sufficient evidence. New research should focus on the symptomatic treatment of the earliest and most salient complaints in AD as well as on disease-modifying interventions acting at the level of the amyloid cascade.

PMID:
23941762
DOI:
10.1159/000353892
[Indexed for MEDLINE]
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