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Antimicrob Agents Chemother. 2013 Nov;57(11):5704-6. doi: 10.1128/AAC.01379-13. Epub 2013 Aug 12.

Microcalorimetry assay for rapid detection of voriconazole resistance in Aspergillus fumigatus.

Author information

1
Unit of Septic Surgery, Lausanne University Hospital, Lausanne, Switzerland.

Abstract

We describe a calorimetric assay for detection of voriconazole-resistant Aspergillus fumigatus within 8 h. Among 27 genetically distinct strains, all 21 resistant and all 6 susceptible strains were correctly identified by measurement of fungal heat production in the presence of voriconazole. This proof-of-concept study demonstrates the potential of microcalorimetry for rapid detection of azole resistance in A. fumigatus.

PMID:
23939893
PMCID:
PMC3811254
DOI:
10.1128/AAC.01379-13
[Indexed for MEDLINE]
Free PMC Article

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