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Rev Panam Salud Publica. 2013 Jun;33(6):414-21.

Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine in Mexico.

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Hospital Para el Niño Poblano, Puebla, Mexico.



To assess the safety and immune responses induced by a 13-valent pneumococcal conjugate vaccine (PCV13) after immunization of infants in Mexico.


PCV13 was given with other routine childhood vaccinations to 225 infants in Mexico at ages 2, 4, 6, and 12 months.


The proportions of subjects achieving immunoglobulin G (IgG) concentrations ≥0.35 µg/mL after the infant series and toddler dose were ≥93.1% and ≥96.7%, respectively, for all 13 serotypes. The serotype-specific pneumococcal IgG geometric mean concentrations after the infant series and toddler dose ranged from 1.18 to 9.13 µg/mL and from 1.62 to 15.41 µg/mL, respectively. The most common local reaction and systemic event after each dose were tenderness and irritability, respectively. Most fever was mild; no fever >40.0°C (i.e., severe) was reported. One subject withdrew because of Kawasaki disease 5 days after the first dose of vaccines, but this condition was not considered related to PCV13.


Overall, PCV13 administered with routine pediatric vaccines was immunogenic and safe in healthy infants in Mexico.

[Indexed for MEDLINE]

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