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Trends Biochem Sci. 2013 Sep;38(9):435-46. doi: 10.1016/j.tibs.2013.07.002. Epub 2013 Aug 9.

A radical sense of direction: signalling and mechanism in cryptochrome magnetoreception.

Author information

1
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK. charlotte.dodson@chem.ox.ac.uk

Abstract

The remarkable phenomenon of magnetoreception in migratory birds and other organisms has fascinated biologists for decades. Much evidence has accumulated to suggest that birds sense the magnetic field of the Earth using photochemical transformations in cryptochrome flavoproteins. In the last 5 years this highly interdisciplinary field has seen advances in structural biology, biophysics, spin chemistry, and genetic studies in model organisms. We review these developments and consider how this chemical signal can be integrated into the cellular response.

KEYWORDS:

cryptochrome; magnetoreception; photolyase; radical pair hypothesis

PMID:
23938034
DOI:
10.1016/j.tibs.2013.07.002
[Indexed for MEDLINE]

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