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J Infect Dis. 2014 Jan 1;209(1):83-6. doi: 10.1093/infdis/jit426. Epub 2013 Aug 9.

Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain.

Author information

1
Clostridia Research Group, Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, School of Life Sciences, University of Nottingham, United Kingdom.

Abstract

Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin mutants of R20291 and assessed their virulence. We demonstrated that either toxin A or toxin B alone can cause fulminant disease in the hamster infection model and present tantalizing data that C. difficile toxin may also contribute to virulence.

KEYWORDS:

CDT; Clostridium difficile infection; TcdA; TcdB; pathogenesis

PMID:
23935202
PMCID:
PMC3864386
DOI:
10.1093/infdis/jit426
[Indexed for MEDLINE]
Free PMC Article

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